Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 7, 2025

Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.3K

The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo

Yanis Berkane1,2,3,4, David M Kostyra5,6, Theodoros Chrelias1

  • 1Department of Plastic, Reconstructive and Aesthetic Surgery, Rennes University Hospital Center, Rennes University, 16 Boulevard de Bulgarie, 35000 Rennes, France.

Bioengineering (Basel, Switzerland)
|December 23, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone Grafting in Le Fort I Osteotomies: Multi-Institutional Data Analysis of Early Outcomes and Risk Factors.

The Journal of craniofacial surgery·2026
Same author

Detection of Microvascular Failure Using Bioimpedance and Sensor-derived Clinical Indicators: A Preliminary Study.

Plastic and reconstructive surgery. Global open·2026
Same author

Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.

Frontiers in immunology·2026
Same author

Hydrogel-Encapsulated Primed MSCs Enhance Regeneration in Full-Thickness Porcine Burn Wounds.

Tissue engineering. Part A·2026
Same author

The Utility and Applicability of the Modified 5-Item Frailty Index in Cosmetic Surgery.

Aesthetic plastic surgery·2026
Same author

Indocyanine green near-infrared fluorescence angiography in free parascapular flaps: Distal flap perfusion assessment in a retrospective study of 112 cases.

JPRAS open·2026

Flap autonomization, the development of new blood vessels in reconstructed tissue, is crucial for healing but poorly understood. This review explores its role in reconstructive surgery and tissue engineering for improved revascularization.

Area of Science:

  • Regenerative Medicine
  • Plastic Surgery
  • Biomaterials Science

Background:

  • Autonomization is a physiological process enabling flap neo-vascularization from the wound bed, fundamental in flap surgeries but not fully understood.
  • Fasciocutaneous flaps have largely replaced muscle flaps due to better outcomes, yet complex cases remain challenging for plastic surgeons.
  • Bioengineering applications like decellularized scaffolds face revascularization hurdles, necessitating a deeper understanding of autonomization.

Purpose of the Study:

  • To compile evidence on flap autonomization phenomena.
  • To systematically review flap autonomization and determine the minimum time required for this process.
  • To discuss current and future applications in bioengineering and tissue engineering, focusing on scaffold revascularization.

Main Methods:

Keywords:
autonomisationautonomizationdecellularizationflap bioengineeringflap neo-vascularizationflap revascularizationscaffold revascularizationtissue engineeringtissue perfusion

More Related Videos

Procurement and Perfusion-Decellularization of Porcine Vascularized Flaps in a Customized Perfusion Bioreactor
10:56

Procurement and Perfusion-Decellularization of Porcine Vascularized Flaps in a Customized Perfusion Bioreactor

Published on: August 1, 2022

2.8K
A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies
05:34

A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

Published on: March 31, 2022

2.4K

Related Experiment Videos

Last Updated: Jul 7, 2025

Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

8.3K
Procurement and Perfusion-Decellularization of Porcine Vascularized Flaps in a Customized Perfusion Bioreactor
10:56

Procurement and Perfusion-Decellularization of Porcine Vascularized Flaps in a Customized Perfusion Bioreactor

Published on: August 1, 2022

2.8K
A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies
05:34

A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

Published on: March 31, 2022

2.4K
  • Systematic literature review focusing on flap autonomization.
  • Analysis of existing evidence regarding the physiological process of neo-vascularization in flaps.
  • Exploration of past and potential applications in regenerative medicine and tissue engineering.

Main Results:

  • The review synthesizes existing evidence on flap autonomization, a critical but poorly understood physiological process.
  • Fasciocutaneous flaps offer improved functional outcomes, but complex reconstructions still present challenges.
  • Understanding autonomization is key for advancing bioengineering, particularly for in vivo revascularization of acellular scaffolds.

Conclusions:

  • Flap autonomization is vital for reconstructive surgery and tissue engineering, enabling neo-vascularization.
  • Further research into autonomization mechanisms can overcome limitations in complex reconstructions and scaffold-based therapies.
  • This phenomenon holds significant potential for improving in vivo revascularization in bioengineered constructs.