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Related Experiment Videos

Maternal compared with infant vitamin D supplementation.

M Ala-Houhala, T Koskinen, A Terho

    Archives of Disease in Childhood
    |December 1, 1986
    PubMed
    Summary
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    Maternal vitamin D supplementation with 2000 IU daily postpartum normalized infant vitamin D levels in winter-born breastfed infants. Lower doses (1000 IU) were insufficient, though infant health remained unaffected.

    Area of Science:

    • Nutritional Science
    • Pediatrics
    • Endocrinology

    Background:

    • Vitamin D is crucial for infant health, particularly for breastfed infants.
    • Maternal supplementation is a potential strategy to ensure adequate infant vitamin D levels.
    • Winter births pose a risk for vitamin D deficiency due to limited sun exposure.

    Purpose of the Study:

    • To evaluate the efficacy of maternal postpartum vitamin D supplementation in normalizing infant vitamin D metabolite levels.
    • To compare the effects of different maternal vitamin D dosages (2000 IU vs. 1000 IU) on exclusively breastfed infants.
    • To assess infant health markers, including mineral levels, parathyroid hormone, alkaline phosphatase, and growth.

    Main Methods:

    • A randomized controlled trial involving 49 healthy mothers and their exclusively breastfed infants.

    Related Experiment Videos

  • Mothers received daily 2000 IU, 1000 IU, or no vitamin D postpartum.
  • Infants in the no-supplementation group received 400 IU of vitamin D daily.
  • Vitamin D metabolites, mineral levels, parathyroid hormone, and alkaline phosphatase were measured at delivery, 8, and 15 weeks postpartum.

    • Main Results:

    • Infant vitamin D concentrations were normalized in the group receiving 2000 IU maternal supplementation, similar to controls.
    • Infants of mothers receiving 1000 IU showed significantly lower vitamin D concentrations at 8 weeks.
    • No significant differences were observed in mineral, parathyroid hormone, or alkaline phosphatase levels between groups.
    • All infants exhibited normal growth and showed no clinical or biochemical signs of rickets.

    Conclusions:

    • Postpartum maternal supplementation with 2000 IU of vitamin D daily effectively normalizes vitamin D metabolites in exclusively breastfed infants born in winter.
    • A daily maternal dose of 1000 IU was insufficient to achieve similar normalization.
    • Further research is needed to assess the long-term maternal safety of this supplementation regimen.