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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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This Special Issue covers pediatric psoriasis and atopic dermatitis (AD) treatments. It details current challenges and recent therapeutic advancements for these common childhood skin conditions.

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Area of Science:

  • Pediatric Dermatology
  • Immunodermatology
  • Clinical Therapeutics

Background:

  • Focuses on the treatment landscape for pediatric psoriasis and atopic dermatitis (AD).
  • Addresses the unique challenges in managing these chronic inflammatory skin diseases in children.
  • Highlights recent therapeutic advancements and their clinical implications.

Discussion:

  • Explores current treatment strategies, including topical and systemic therapies.
  • Discusses the unmet needs and limitations of existing pediatric dermatological treatments.
  • Examines the evolving understanding of disease mechanisms in young patients.

Key Insights:

  • Summarizes key findings on the efficacy and safety of novel treatments for pediatric AD and psoriasis.
  • Identifies critical factors influencing treatment response and long-term outcomes.
  • Emphasizes the importance of age-appropriate and evidence-based therapeutic approaches.

Outlook:

  • Projects future directions in pediatric psoriasis and AD management.
  • Suggests areas for further research and clinical investigation.
  • Anticipates the integration of new biologics and targeted therapies into standard care.