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NADES-Assisted Extraction of Polyphenols from Coriander Seeds: A Systematic Optimization Study.

Federica Ianni¹, Samir Scandar², Luciano Mangiapelo¹

¹Department of Pharmaceutical Sciences, Section of Food, Biochemical, Physiological and Nutrition Sciences, University of Perugia, 06126 Perugia, Italy.

Antioxidants (Basel, Switzerland)

|December 23, 2023

Summary

This summary is machine-generated.

This study explored natural deep eutectic solvents (NADES) for extracting polyphenols from coriander seeds. Optimized NADES and extraction methods, like ultrasound-assisted extraction (UAE), efficiently recovered specific phenolic acids and rutin.

Keywords:

HPLC-DAD monitoring NADES antioxidant activity coriander seeds polyphenols

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Area of Science:

Agricultural and Food Chemistry
Natural Product Chemistry
Green Chemistry

Background:

Coriandrum sativum L. seeds are traditionally used in medicine, with known nutritional components like linalool and petroselinic acid.
The polyphenolic fraction of coriander seeds remains underexplored, necessitating advanced extraction techniques.
Natural Deep Eutectic Solvents (NADES) offer a sustainable approach for extracting bioactive compounds from plant materials.

Purpose of the Study:

To develop a one-step methodology for recovering polyphenols from coriander seeds using NADES.
To evaluate the efficacy of different NADES (choline chloride-based) combined with maceration (MAC) and ultrasound-assisted extraction (UAE).
To systematically optimize polyphenol extraction by modulating NADES composition and extraction techniques.

Main Methods:

Green extraction using various NADES, including choline chloride-citric acid (ChCl:CA), choline chloride-urea (ChCl:Ur), and choline chloride-glucose (ChCl:Glu).
Comparison of conventional maceration (MAC) and non-conventional ultrasound-assisted extraction (UAE) techniques.
Quantitative analysis of extracted polyphenols, including chlorogenic acid, its isomer, protocatechuic acid, caffeic acid, p-coumaric acid, and rutin.

Main Results:

ChCl:Ur combined with UAE significantly enhanced the extraction of chlorogenic acid and its isomer.
ChCl:Glu with UAE improved the recovery of protocatechuic, caffeic, and p-coumaric acids.
The highest rutin yield was achieved using ChCl:CA-based NADES with the MAC technique.

Conclusions:

NADES composition can be tailored to selectively enhance the extraction of specific polyphenols from coriander seeds.
The combination of NADES with UAE or MAC provides an efficient, one-step method for recovering valuable bioactive compounds.
This approach holds potential for the targeted isolation of desirable phenolics for various applications.