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Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Lolita Kursvietiene1, Dalia M Kopustinskiene2, Inga Staneviciene1

  • 1Department of Biochemistry, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50009 Kaunas, Lithuania.

Antioxidants (Basel, Switzerland)
|December 23, 2023
PubMed

Insights

Resveratrol, a natural polyphenol, exhibits broad anti-cancer effects by influencing apoptosis, cell cycle, and metastasis. Further research into its molecular targets will aid its clinical use in cancer therapy.

Area of Science:

  • Oncology
  • Phytochemistry
  • Molecular Biology

Background:

  • Cancer poses a significant global health challenge, necessitating novel therapeutic strategies.
  • Phytochemicals, especially polyphenols like resveratrol, are gaining attention for their potential anti-cancer properties.

Purpose of the Study:

  • To review the multifaceted anti-cancer effects of resveratrol.
  • To discuss resveratrol's impact on key cancer hallmarks and mitochondrial function.
  • To identify future research directions for clinical translation.

Main Methods:

  • Literature review of studies on resveratrol's anti-cancer mechanisms.
  • Analysis of resveratrol's effects on apoptosis, cell cycle, inflammation, angiogenesis, metastasis, cancer stem cells, and the tumor microenvironment.
  • Discussion of resveratrol's influence on mitochondrial functions in cancer.

Main Results:

  • Resveratrol demonstrates pleiotropic anti-cancer activities.
  • It modulates critical cellular processes including apoptosis, cell cycle progression, and angiogenesis.
  • Resveratrol impacts cancer stem cells, the tumor microenvironment, and mitochondrial function.

Conclusions:

  • Resveratrol shows significant promise as a therapeutic agent for cancer prevention and treatment.
  • Elucidating specific molecular targets is crucial for advancing resveratrol's clinical application.
  • Further research is warranted to fully harness resveratrol's potential in oncology.
Keywords:
cancermitochondriaresveratrol

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