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Fluoride treatment in corticosteroid induced osteoporosis
Archives of Disease in Childhood
|December 1, 1986
Summary
Prolonged high-dose corticosteroids for dermatomyositis can cause severe osteoporosis and fractures in children. Sodium fluoride, calcium, and vitamin D may help manage this secondary osteoporosis.
Area of Science:
- Pediatric Endocrinology
- Rheumatology
- Bone Metabolism
Background:
- Relapsing dermatomyositis often requires prolonged high-dose corticosteroid therapy.
- Corticosteroid-induced osteoporosis is a significant concern in pediatric patients undergoing long-term treatment.
Observation:
- Two young female patients developed severe osteoporosis with multiple vertebral fractures.
- These fractures occurred during extended high-dose corticosteroid treatment for refractory dermatomyositis.
Findings:
- Sodium fluoride, in conjunction with calcium and vitamin D supplementation, demonstrated efficacy in managing secondary osteoporosis in one patient.
- This therapeutic approach warrants consideration for treating corticoid-induced osteoporosis.
Implications:
- Highlights the risk of severe bone complications from prolonged corticosteroid use in pediatric rheumatology.
- Suggests a potential treatment strategy for managing corticosteroid-induced osteoporosis in children.
- Emphasizes the importance of monitoring bone health in pediatric patients with chronic inflammatory diseases requiring immunosuppressive therapy.