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The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation

Taline Lazzarin1, Danilo Martins1, Raquel S Ballarin1

  • 1Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18600-000, Brazil.

Antioxidants (Basel, Switzerland)
|December 23, 2023
PubMed

Insights

Omega-3 fatty acids show promise in reducing cardiac remodeling, a major cause of heart disease mortality. This review explores their antioxidant and anti-inflammatory benefits as a complementary therapy.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Cardiac remodeling involves detrimental changes in heart size, shape, and function.
  • Current pharmacological treatments for cardiac remodeling have limited efficacy, leading to high mortality rates.

Purpose of the Study:

  • To review the potential of omega-3 fatty acids as an adjunctive therapy for cardiac remodeling.
  • To highlight the antioxidant and anti-inflammatory mechanisms of omega-3 in mitigating cardiac remodeling.

Main Methods:

  • Literature review of studies investigating omega-3 fatty acids and cardiac remodeling.
  • Analysis of biochemical and cellular mechanisms underlying omega-3's effects.

Main Results:

  • Omega-3 fatty acids possess significant antioxidant and anti-inflammatory properties.
  • These properties suggest a role for omega-3 in attenuating molecular, cellular, and interstitial changes in cardiac remodeling.

Conclusions:

  • Omega-3 fatty acids represent a promising adjunctive therapy to reduce cardiac remodeling.
  • Further research is warranted to establish optimal use and efficacy in clinical settings.

Keywords:
cardiac failurefatty acidsomega-3oxidative stressremodeling

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