Superparamagnetic Artificial Cells PLGA-Fe₃O₄ Micro/Nanocapsules for Cancer Targeted Delivery

Artificial cells have been extensively used in many fields, such as nanomedicine, biotherapy, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, and the COVID-19 vaccine. The unique properties of superparamagnetic Fe₃O₄ nanoparticles have contributed to increased interest in using superparamagnetic artificial cells (PLGA-Fe₃O₄ micro/nanocapsules) for targeted therapy. In this review, the preparation methods of Fe₃O₄ NPs and superparamagnetic artificial cell PLGA-drug-Fe₃O₄ micro/nanocapsules are discussed. This review also focuses on the recent progress of superparamagnetic PLGA-drug-Fe₃O₄ micro/nanocapsules as targeted therapeutics. We shall concentrate on the use of superparamagnetic artificial cells in the form of PLGA-drug-Fe₃O₄ nanocapsules for magnetic hyperthermia/photothermal therapy and cancer therapies, including lung breast cancer and glioblastoma.