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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Prostate Cancers Invisible on Multiparametric MRI: Pathologic Features in Correlation with Whole-Mount Prostatectomy.

Aritrick Chatterjee1,2, Alexander Gallan3, Xiaobing Fan1,2

  • 1Department of Radiology, University of Chicago, Chicago, IL 60637, USA.

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|December 23, 2023
PubMed
Summary
This summary is machine-generated.

Smaller, lower-grade prostate cancers (PCas) are harder to detect with multiparametric MRI (mpMRI). Unique tissue composition, with more lumen and less epithelium, explains why some PCas are missed on mpMRI scans.

Keywords:
MRIinvisible lesionprostate cancertissue composition

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Area of Science:

  • Radiology
  • Oncology
  • Pathology

Background:

  • Multiparametric MRI (mpMRI) is crucial for prostate cancer (PCa) detection.
  • However, some PCas are not identified on mpMRI, impacting diagnosis and treatment.
  • Understanding the characteristics of these unidentified cancers is essential for improving detection rates.

Purpose of the Study:

  • To investigate the reasons why certain prostate cancers are missed by mpMRI.
  • To correlate imaging findings with histopathological features of identified and unidentified PCas.

Main Methods:

  • Whole-mount prostatectomy specimens were used as the ground truth for 61 patients with biopsy-confirmed PCa.
  • 3T mpMRI was performed, and cancers were classified as identified (ICs) or unidentified (UCs) by correlating with histology.
  • Quantitative histology assessed Gleason score, stage, size, cancer gland density, and tissue composition (epithelium, lumen).

Main Results:

  • Of 115 cancers, 19 (16.5%) were unidentified on mpMRI.
  • UCs were significantly smaller, had lower Gleason scores and clinical stages than ICs.
  • UCs showed higher ADC and T2 values, lower cancer gland density, lower epithelium percentage, and higher lumen volume compared to ICs.

Conclusions:

  • Prostate cancer characteristics, including smaller size, lower grade, and specific tissue composition (higher lumen, lower epithelium), contribute to their undetectability on mpMRI.
  • These findings highlight the limitations of mpMRI in detecting all PCas and suggest areas for future imaging technique development.