Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothermia-induced reversible platelet dysfunction.

C R Valeri, H Feingold, G Cassidy

    Annals of Surgery
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Commentary on 50 years of research at the NBRL, Boston, Massachusetts.

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2016
    Same author

    Osteoporosis in people with intellectual disabilities: a review and a brief study of risk factors for osteoporosis in a community sample of people with intellectual disabilities.

    Journal of intellectual disability research : JIDR·2010
    Same author

    Massive transfusion in patients with severe traumatic injuries.

    Vox sanguinis·2009
    Same author

    Role of nitric oxide in the prevention of severe adverse events associated with blood products.

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2008
    Same author

    [Rhabdomyolysis in a worker exposed to paraffinic mineral oils. Unusual association with bronchiolitis obliterans and organizing pneumonia (BOOP)].

    Giornale italiano di medicina del lavoro ed ergonomia·2008
    Same author

    Prevention of TRALI.

    Vox sanguinis·2007
    Same journal

    Real-world Safety and Performance of the Symani Surgical System® in Microsurgical Reconstructive Procedures: Primary Results from the PRIMO Study.

    Annals of surgery·2026
    Same journal

    Revisiting Simultaneous Liver and Kidney Transplantation from Donors After Circulatory Death in the Era of Machine Perfusion Technologies: A US Nationwide Analysis of 10,687 Cases.

    Annals of surgery·2026
    Same journal

    The International Medical Graduate Paradox.

    Annals of surgery·2026
    Same journal

    Defining the Incremental Value of Endoscopic Ultrasound in Assessing Pancreatic Cystic Neoplasms.

    Annals of surgery·2026
    Same journal

    Trends in Metabolic and Bariatric Surgery and GLP-1 Receptor Agonist Use Among Adolescents with Severe Obesity.

    Annals of surgery·2026
    Same journal

    The Ambulatory Surgery Center Paradox: Why 60% of Surgeries Occur Where 2% of AI Research Happens.

    Annals of surgery·2026
    See all related articles

    Hypothermia impairs blood clotting by causing reversible platelet dysfunction. Restoring normal skin temperature significantly reduces bleeding time in both hypothermic and normothermic baboons.

    Area of Science:

    • Physiology
    • Hematology
    • Biomedical Research

    Background:

    • Systemic hypothermia can affect hemostasis.
    • Platelet function is crucial for blood clotting.

    Purpose of the Study:

    • To investigate the effect of local skin temperature on bleeding time.
    • To explore the relationship between skin temperature, bleeding time, and thromboxane B2 levels.
    • To understand the impact of temperature on platelet function.

    Main Methods:

    • Experiments were conducted on baboons subjected to systemic hypothermia and normothermia.
    • Arm skin temperature was manipulated (warming and cooling).
    • Bleeding time was measured using the template bleeding time method.
    • Thromboxane B2 levels in shed blood were analyzed.

    Related Experiment Videos

    Main Results:

    • Local warming of arm skin reduced bleeding time in hypothermic baboons.
    • Cooling arm skin increased bleeding time in normothermic baboons.
    • A significant negative correlation was found between bleeding time and arm skin temperature.
    • A significant positive correlation was observed between thromboxane B2 levels and arm skin temperature.
    • Platelet thromboxane B2 production is temperature-dependent, leading to reversible platelet dysfunction upon cooling.

    Conclusions:

    • Restoring normal skin temperature is critical for improving hemostasis in hypothermic patients.
    • Temperature management can influence bleeding complications and potentially reduce the need for blood product transfusions.