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Updated: Jul 7, 2025

Single Oocyte Bisulfite Mutagenesis
Published on: June 27, 2012
A DNA Methylation Perspective on Infertility
Ghaleb Shacfe1, Rasoul Turko1, Haadi Hammad Syed1
1College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Abstract:
Infertility affects a significant number of couples worldwide and its incidence is increasing. While assisted reproductive technologies (ART) have revolutionized the treatment landscape of infertility, a significant number of couples present with an idiopathic cause for their infertility, hindering effective management. Profiling the genome and transcriptome of infertile men and women has revealed abnormal gene expression. Epigenetic modifications, which comprise dynamic processes that can transduce environmental signals into gene expression changes, may explain these findings. Indeed, aberrant DNA methylation has been widely characterized as a cause of abnormal sperm and oocyte gene expression with potentially deleterious consequences on fertilization and pregnancy outcomes. This review aims to provide a concise overview of male and female infertility through the lens of DNA methylation alterations.
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