Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress.

Pharmacology, biochemistry, and behavior·2026

Same author

Tobacco and Nicotine Dependence Vulnerability as a Function of Dopaminergic Dysregulation: Proposing a Novel Strategy to Promote Neurotransmitter Homeostasis.

Current neuropharmacology·2026

Same author

Corrigendum to "Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice" [Neurosci. Lett. 878 (2026) 138558].

Neuroscience letters·2026

Same author

Reward Deficiency Syndrome (RDS): A Common Neurogenetic Trait/State of All Addictions: Is this the new DSM?

British journal of healthcare and medical research·2026

Same author

Sustained Attention Instability as a Cognitive Biomarker in Chronic Spine Pain: A 90-second Visual Attention Test.

European journal of pain (London, England)·2026

Same author

A Personalized Medicine Approach: Psychosocial and Genetic Risk Assessments Predictors of Bariatric Surgery Outcomes After 3 Years.

Biomedicines·2026

Search research articles

Related Experiment Video

Updated: Jul 7, 2025

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

Exercise Modifies the Brain Metabolic Response to Chronic Cocaine Exposure Inhibiting the Stria Terminalis.

Colin Hanna¹, Rutao Yao², Munawwar Sajjad²

¹Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacob School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.

|December 23, 2023

Summary

Aerobic exercise alters brain glucose metabolism in cocaine-exposed rats, affecting regions involved in reward and stress. This research highlights exercise

Keywords:

18F-FDG fluorodeoxyglucose aerobic exercise cocaine glucose metabolism positron emission tomography rat statistical parametric mapping

More Related Videos

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Related Experiment Videos

Last Updated: Jul 7, 2025

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Area of Science:

Neuroscience
Exercise Physiology
Addiction Research

Background:

Exercise is known to benefit mental and physiological health.
Physical activity plays a protective role in various diseases, including neurological and psychiatric conditions.
Understanding exercise's impact on the brain's response to drugs of abuse is crucial.

Purpose of the Study:

To investigate the effects of aerobic exercise on brain glucose metabolism in female rats with chronic cocaine exposure.
To identify specific brain regions where metabolic activity is altered by exercise in the context of cocaine use.

Main Methods:

Utilizing positron emission tomography (PET) with [18F]-Fluorodeoxyglucose (FDG) to measure brain glucose metabolism.
Comparing brain metabolic activity between an exercise group (treadmill running for six weeks) and a sedentary control group, both exposed to chronic cocaine.
Analyzing metabolic changes in distinct brain regions.

Main Results:

Aerobic exercise led to significant metabolic changes in response to chronic cocaine exposure.
Observed activation in the secondary visual cortex.
Observed inhibition in the cerebellum, stria terminalis, thalamus, caudate putamen, and primary somatosensory cortex.

Conclusions:

Chronic aerobic exercise can modify the brain's metabolic response to cocaine treatment.
These alterations occur in brain circuits associated with emotion, behavior, and the reward system.
Findings support exercise as a potential modulator of the brain's response to drugs of abuse, offering avenues for future research in addiction and neuroscience.