Preventive Therapies in Peripheral Arterial Disease

Area of Science:

• Cardiovascular Medicine
• Vascular Biology
• Public Health

Background:

• Atherosclerosis is now understood as an inflammatory process, not just cell proliferation.
• Peripheral artery disease (PAD) incidence and its associated healthcare burden are increasing globally.
• Lipoproteins and their remnants are key contributors to atherosclerotic plaque development.

Purpose of the Study:

• To review the epidemiology, pathophysiology, and clinical presentation of PAD.
• To highlight the critical need for understanding PAD given its significant global impact.
• To discuss therapeutic strategies for preventing adverse cardiovascular and limb events in PAD patients.

Main Methods:

• Literature review focusing on atherosclerosis and peripheral artery disease.
• Synthesis of current knowledge on PAD pathophysiology and clinical manifestations.
• Analysis of therapeutic approaches for managing PAD complications.

Main Results:

• PAD is linked to poor cardiovascular and limb outcomes.
• Understanding PAD's multifactorial nature is crucial for effective management.
• Established role of lipoproteins in atherosclerotic disease progression.

Conclusions:

• PAD represents a significant and escalating global health challenge.
• Comprehensive knowledge of PAD's epidemiology, pathophysiology, and presentation is essential.
• Therapeutic interventions are vital for mitigating major adverse events in PAD.