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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jul 7, 2025

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Nucleic Acid Aptamer-Based Biosensors: A Review.

Beatriz Sequeira-Antunes^1,2,3, Hugo Alexandre Ferreira^1,2

¹Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016 Lisboa, Portugal.

|December 23, 2023

Summary

Aptasensors, utilizing aptamers, offer superior alternatives to antibodies in biosensors for rapid point-of-care diagnostics. These advanced biosensors detect various disease biomarkers, significantly improving healthcare delivery.

Keywords:

SELEX process aptamers aptasensors biomarkers electrical aptasensors magnetic aptasensors optical aptasensors point of care

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Area of Science:

Biotechnology
Biomedical Engineering
Molecular Diagnostics

Background:

Aptamers, DNA/RNA/peptide molecules, exhibit high specificity and affinity for target molecules.
Aptasensors integrate aptamers into biosensor platforms for advanced diagnostics.
Aptamers present advantages over traditional antibodies in biosensor applications.

Purpose of the Study:

To review the advantages of aptamers over antibodies in biosensors.
To explore aptamers for detecting biomarkers in infectious diseases, cancer, cardiovascular, metabolic, and neurological disorders.
To discuss binding assays, transducer techniques, and the current state of aptasensor diagnostics.

Main Methods:

Literature review of aptamer technology and biosensor applications.
Analysis of aptamer selection and characterization methods.
Examination of various aptasensor formats and detection principles.

Main Results:

Aptamers offer enhanced specificity, stability, and ease of modification compared to antibodies.
Aptasensors demonstrate significant potential for detecting a wide range of disease biomarkers.
Diverse binding assays and transducer technologies facilitate aptasensor development.

Conclusions:

Aptasensors represent a powerful tool for point-of-care diagnostics.
These technologies hold immense potential for revolutionizing healthcare delivery through improved diagnostics.
Continued research in aptasensor development promises further advancements in personalized medicine.