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Dynamic Pupillary Response in Multiple Sclerosis Patients with and without Optic Neuritis
Amparo Gil-Casas1, David P Piñero2, Ainhoa Molina-Martín2
1Optometric Clinic, Foundation Lluís Alcanyís, University of Valencia, 46020 Valencia, Spain.
Biomedicines
|December 23, 2023
Summary
Pupillary responses in multiple sclerosis (MS) patients were analyzed. Only those with prior optic neuritis (ON) showed significant differences in contraction latency and amplitude compared to healthy individuals.
Area of Science:
- Neuro-ophthalmology
- Neurodegenerative diseases
Background:
- Multiple sclerosis (MS) is a central nervous system neurodegenerative disease.
- MS can cause visual dysfunction, including abnormal pupillary responses, even after optic neuritis (ON).
Purpose of the Study:
- To evaluate pupillary response parameters in MS patients with and without a history of ON.
- To compare these parameters against healthy controls.
Main Methods:
- Pupillary parameters (e.g., amplitude, latency, velocity) were measured using the MYAH topographer.
- Data from 22 MS patients, 13 MS patients with prior ON (MSON), and 24 healthy controls were analyzed.
- Statistical analysis employed IBM SPSS Statistics with appropriate parametric or non-parametric tests.
Main Results:
- MS patients generally did not differ significantly from healthy controls in pupillary parameters.
- MSON patients exhibited significantly different contraction amplitude and latency compared to healthy individuals.
- Abnormal pupillary recovery times were observed in a small percentage of both MS (9%) and MSON (12%) subjects.
Conclusions:
- The pupillary contraction process, specifically latency and amplitude, is affected in MS patients with a history of ON.
- Further research is needed to explore the relationship between pupillary response deficits, MS disability, and comorbidities like ON.
