Related Experiment Video
Updated: Jul 7, 2025
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Postprandial Dysmetabolism and Its Medical Implications
Emanuel Sasso1, Lara Baticic2, Vlatka Sotosek3
1Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia.
Life (Basel, Switzerland)
|December 23, 2023
Summary
An unhealthy diet can cause chronic inflammation, increasing risks for diseases and cancer. A balanced diet with anti-inflammatory foods may prevent these conditions by modulating the immune system.
Area of Science:
- Immunology
- Nutrition Science
- Oncology
Background:
- Unbalanced diets are linked to chronic diseases and cancers globally.
- Low-grade systemic chronic inflammation, driven by innate immune system activation, underlies these pathologies.
- Dietary factors significantly influence chronic inflammatory diseases.
Purpose of the Study:
- To review the role of innate immune system-mediated inflammatory responses in chronic diseases and cancer.
- To explore the potential of dietary interventions in preventing inflammation-related diseases.
- To discuss future research directions in immune regulation for disease prevention.
Main Methods:
- Literature review of studies on diet, inflammation, and chronic diseases.
- Analysis of the dual role of immune cells in inflammation and disease.
- Examination of the link between diet, innate immunity, and pathologies like hyperglycemia, obesity, and cancer.
Main Results:
- Chronic inflammation from constant innate immune activation is a key factor in disease development.
- Dietary components can either promote or combat inflammation.
- Immune cells exhibit a dual function, potentially shifting from pro-tumor to anti-tumorigenic.
Conclusions:
- A balanced, anti-inflammatory diet can prevent chronic diseases and cancer.
- Modulating innate immune cells offers a promising strategy for therapeutic intervention.
- Future research should focus on gene-diet interactions and immune cell reprogramming.
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