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Plasmapheresis in the ICU.

Guleid Hussein1, Bolun Liu1, Sumeet K Yadav1

  • 1Mayo Clinic Health System, Mankato, MN 56001, USA.

Medicina (Kaunas, Lithuania)
|December 23, 2023
PubMed
Summary
This summary is machine-generated.

Therapeutic plasma exchange (TPE) removes harmful substances from the blood. This review covers TPE principles, uses in intensive care units (ICUs), and future possibilities for critical care.

Keywords:
ICUTPEplasmapheresis

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Area of Science:

  • Critical care medicine
  • Nephrology
  • Immunology

Background:

  • Therapeutic plasma exchange (TPE) is an extracorporeal procedure designed to remove harmful molecules from a patient's plasma.
  • It involves replacing the patient's plasma with a substitute fluid, effectively clearing circulating toxins or autoantibodies.
  • TPE is utilized across various critical care settings for diverse disease management.

Purpose of the Study:

  • To review the fundamental principles of Therapeutic Plasma Exchange.
  • To outline the current clinical applications of TPE in intensive care units (ICUs).
  • To explore potential future directions and advancements in TPE for critical care.

Main Methods:

  • Review of existing literature on TPE principles and applications.
  • Analysis of TPE's role in different critical care disease states.
  • Discussion of emerging trends and future research in TPE.

Main Results:

  • TPE functions as both a primary treatment and a salvage therapy in critical care.
  • Established applications include autoimmune diseases, thrombotic microangiopathies, and certain poisonings.
  • The review highlights the versatility and efficacy of TPE in managing complex critical illnesses.

Conclusions:

  • Therapeutic plasma exchange is a vital tool in critical care, offering a method for removing harmful plasma components.
  • Its application spectrum is broad, ranging from first-line therapy to salvage treatment for various critical conditions.
  • Future research may expand TPE's utility and refine its application in intensive care medicine.