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Related Experiment Video

Updated: Jul 7, 2025

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Microfiber-Patterned Versatile Perfusable Vascular Networks.

Ye Tian^1,2, Liqiu Wang³

¹College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China.

|December 23, 2023

Summary

This summary is machine-generated.

A new microfiber-patterned method rapidly creates versatile, perfusable vascular networks in vitro. This technique precisely controls vascular geometry for applications in tissue engineering and drug development.

Keywords:

blood vessel microfiber microfiber-patterned vascular networks

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Last Updated: Jul 7, 2025

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Published on: April 4, 2018

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks

Published on: January 3, 2017

Area of Science:

Biomaterials Science
Microfluidics
Tissue Engineering

Background:

Fabricating perfusable vascular networks with controlled cylindrical channels in vitro remains a significant challenge.
Existing methods often lack the precision and speed required for versatile network construction.

Purpose of the Study:

To develop a rapid and precise method for constructing versatile perfusable vascular networks with cylindrical channels.
To demonstrate the potential of these networks for mimicking in vivo vascular structures and functions.

Main Methods:

Utilized a novel microfiber-patterned technique employing tensile microfibers as removable templates.
Fabricated chips with 1D, 2D, 3D, and multilayered structures for precise control over vascular geometry.
Co-cultured human umbilical vein endothelial cells (HUVECs) within the 3D networks to assess endothelialization.

Main Results:

Successfully generated well-controlled perfusable vascular networks with customizable cylindrical channels.
Demonstrated precise control over vascular geometry across various dimensionalities (1D, 2D, 3D, multilayered).
Confirmed excellent HUVEC attachment, viability, and formation of endothelial tubular lumens within the channels.

Conclusions:

The microfiber-patterned method offers a simple, rapid, and low-cost approach for creating versatile perfusable vascular networks.
These engineered vascular networks show significant potential for applications in microfluidics, tissue engineering, clinical medicine, and drug development.
The technique facilitates the creation of biomimetic vascular models for advanced research.