Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kinematic Equations - II01:17

Kinematic Equations - II

9.5K
The second kinematic equation expresses the final position of an object in terms of its initial position, the distance traveled with the initial constant velocity, and the distance traveled due to a change in velocity. Similar to the first kinematic equation, this equation is also only valid when the acceleration is constant throughout the motion of an object.
Suppose a car merges into freeway traffic on a 200 m long ramp. If its initial velocity is 10 m/s and it accelerates at 2 m/s2, then the...
9.5K
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

35.2K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
35.2K
Kinematic Equations - I01:26

Kinematic Equations - I

10.6K
When an object moves with constant acceleration, the velocity of the object changes at a constant rate throughout the motion. The kinematic equations of motions are derived for such cases where the acceleration of the object is constant. The first kinematic equation gives an insight into the relationship between velocity, acceleration, and time. We can see, for example:
10.6K
Measuring Reaction Rates03:09

Measuring Reaction Rates

25.1K
Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
25.1K
Kinematic Equations: Problem Solving01:15

Kinematic Equations: Problem Solving

12.5K
When analyzing one-dimensional motion with constant acceleration, the problem-solving strategy involves identifying the known quantities and choosing the appropriate kinematic equations to solve for the unknowns. Either one or two kinematic equations are needed to solve for the unknowns, depending on the known and unknown quantities. Generally, the number of equations required is the same as the number of unknown quantities in the given example. Two-body pursuit problems always require two...
12.5K
Kinematic Equations - III01:18

Kinematic Equations - III

7.6K
The first two kinematic equations have time as a variable, but the third kinematic equation is independent of time. This equation expresses final velocity as a function of the acceleration and distance over which it acts. The fourth kinematic equation does not have an acceleration term and provides the final position of the object at time t in terms of the initial and final velocities. This equation is useful when the value of the constant acceleration is unknown.
Using the kinematic equations,...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deciphering the Molecular Mechanisms of Tau K18 Liquid-Liquid Phase Separation and Its Phosphorylation/RNA-Mediated Modulation via Coarse-Grained Simulations.

Journal of chemical information and modeling·2026
Same author

Efficient and Precise Force Field Optimization for Biomolecules Using DPA-3.

Journal of chemical information and modeling·2026
Same author

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

Journal of chemical information and modeling·2026
Same author

Robust Prediction of Protein-Ligand Binding Potency with Multi-modal Customized Gate Control.

Journal of chemical information and modeling·2025
Same author

Intermolecular Interaction, Electronic Structure and Aromaticity of Possible Dimers of Cyclo[18]Carbon (C<sub>18</sub>).

Chemphyschem : a European journal of chemical physics and physical chemistry·2025
Same author

True Dynamics of Pillararene Host-Guest Binding.

Journal of chemical theory and computation·2024
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
Same journal

Comparative Phytochemical Studies on the Aerial Parts of <i>Teucrium davaeanum</i> Coss. and <i>Teucrium zanonii</i> Pamp.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jul 7, 2025

A Protocol for Real-time 3D Single Particle Tracking
10:16

A Protocol for Real-time 3D Single Particle Tracking

Published on: January 3, 2018

14.9K

Accelerating Kinetics with Time-Reversal Path Sampling.

Zhirong Liu1

  • 1Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Molecules (Basel, Switzerland)
|December 23, 2023
PubMed
Summary
This summary is machine-generated.

A new time-reversal path sampling (tRPS) method accelerates simulations for determining transition rates. This approach enhances efficiency by up to five orders of magnitude for complex molecular processes.

Keywords:
accelerated kineticsenhanced samplingnonequilibrium statisticsprotein foldingtime reversibility

More Related Videos

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

8.5K
Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

9.0K

Related Experiment Videos

Last Updated: Jul 7, 2025

A Protocol for Real-time 3D Single Particle Tracking
10:16

A Protocol for Real-time 3D Single Particle Tracking

Published on: January 3, 2018

14.9K
Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

8.5K
Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

9.0K

Area of Science:

  • Computational Chemistry and Physics
  • Biophysics
  • Statistical Mechanics

Background:

  • Enhanced sampling methods are crucial for simulating complex molecular systems.
  • Existing methods for equilibrium thermodynamics are abundant, but accelerating simulations for kinetics and nonequilibrium statistics remains challenging.
  • Efficiently determining transition rates between free-energy basins is vital for understanding molecular dynamics.

Purpose of the Study:

  • To introduce and validate a novel time-reversal path sampling (tRPS) method.
  • To significantly accelerate simulations for calculating transition rates in stochastic processes.
  • To provide an efficient alternative to direct simulation methods for kinetics.

Main Methods:

  • Derivation of the time-reversal path sampling (tRPS) method based on microscopic time reversibility.
  • Implementation involves forward and backward shooting simulations from transition-state regions to basin minima.
  • Assembly of paths to efficiently obtain the distribution of transition paths.

Main Results:

  • The tRPS method effectively converts difficult uphill path sampling into a simpler downhill problem.
  • Demonstrated efficiency increase of up to five orders of magnitude compared to direct simulations.
  • Results from tRPS are consistent with direct simulations for protein folding and unfolding.

Conclusions:

  • The tRPS method offers a significant advancement in accelerating kinetic simulations.
  • This approach is broadly applicable to various stochastic processes exhibiting microscopic reversibility.
  • tRPS provides a computationally efficient and reliable tool for studying molecular transitions.