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Updated: Jul 7, 2025
11:31
Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
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Extracellular Vesicles as Delivery Systems in Disease Therapy
Manuel Alejandro Picon1, Liyong Wang2, Andrea Da Fonseca Ferreira1
1Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
International Journal of Molecular Sciences
|December 23, 2023
Summary
Extracellular vesicles (EVs) are key for cell communication and disease. This review explores their use in gene editing, cancer therapy, drug delivery, and vaccines.
Area of Science:
- Biotechnology
- Cell Biology
- Nanomedicine
Background:
- Extracellular vesicles (EVs) are nanoparticles involved in intercellular communication.
- Their structure protects cargo and targets specific cells, influencing disease pathogenesis.
- EVs are being investigated for therapeutic applications, including vaccine delivery.
Purpose of the Study:
- To review the diverse platforms utilizing EVs as delivery vehicles.
- To highlight applications in gene editing, cancer therapy, drug delivery, and vaccines.
- To discuss the role of EVs in disease development.
Main Methods:
- Literature review of studies on EV applications.
- Analysis of EV-based platforms for gene editing (CRISPR/Cas9).
- Examination of therapeutic strategies using EVs for cancer, drug delivery, and vaccines.
Main Results:
- EVs show promise as delivery systems for mRNA vaccines and gene editing tools.
- Therapeutic strategies leverage EVs for targeted delivery of microRNAs and mRNA.
- EVs play a significant role in various disease pathologies.
Conclusions:
- EVs represent a versatile platform for advanced therapeutic delivery systems.
- Further research into EV-based therapies holds significant potential for medicine.
- Understanding EV roles in disease is crucial for developing novel treatments.
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