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Disrupting Poly(ADP-ribosyl)ating Pathway Creates Premalignant Conditions in Mammalian Liver

Yaroslava Karpova1,2, David J Orlicky3, Edward E Schmidt4,5,6

  • 1Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58202, USA.

International Journal of Molecular Sciences
|December 23, 2023
PubMed
Summary

Poly(ADP-ribosyl)ation is crucial for normal hepatocyte maturation. Disrupting this pathway in mice leads to liver inflammation and a higher risk of developing hepatocellular carcinoma (HCC).

Keywords:
PARGPARP1ductal responsehepatocellular carcinomahepatocyte maturationpoly(ADP-ribose) glycohydrolasepoly(ADP-ribose) polymerasetumorigenesis

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