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Updated: Jul 7, 2025

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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
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Current Insights on Lipid-Based Nanosystems 2023
Ana Catarina Silva1,2,3, João Nuno Moreira4,5, José Manuel Sousa Lobo1,2
1UCIBIO (Research Unit on Applied Molecular Biosciences), REQUIMTE (Rede de Química e Tecnologia), MEDTECH (Medicines and Healthcare Products), Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Pharmaceuticals (Basel, Switzerland)
|December 23, 2023
Summary
Lipid-based nanosystems are highly effective for drug delivery across various administration routes. Their unique properties enhance drug transport and therapeutic efficacy compared to non-lipid alternatives.
Area of Science:
- Nanomedicine
- Drug Delivery Systems
- Biotechnology
Background:
- Lipid-based nanosystems are extensively researched for therapeutic applications.
- They offer significant advantages over non-lipid nanosystems.
- Key benefits include enhanced drug transport and efficacy.
Discussion:
- Exploration of lipid-based nanosystems for diverse administration routes (ocular, cutaneous, intranasal, intravenous).
- Advantages in improving drug bioavailability and targeted delivery.
- Potential for overcoming biological barriers in drug administration.
Key Insights:
- Lipid nanosystems demonstrate superior performance in drug delivery.
- Proven efficacy across multiple administration pathways.
- Significant potential for advancing therapeutic treatments.
Outlook:
- Further development of lipid-based nanosystems for novel drug formulations.
- Expanding applications in targeted and personalized medicine.
- Continued innovation in nanocarrier technology for enhanced therapeutics.

