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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
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Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke.

Chengting Jiang1,2, Yang Zhou3, Rong Chen2

  • 1Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming 650500, China.

Pharmaceutics
|December 23, 2023
PubMed
Summary

Nanomaterial drug delivery systems offer improved treatments for ischemic stroke by enhancing drug effectiveness and reducing side effects. This review explores nanocarriers, targeting ligands, and release triggers for optimized ischemic stroke therapies.

Keywords:
drug deliveryischemic strokenanomaterialsnanoparticlestargeted therapy

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Neurology

Background:

  • Ischemic stroke is a major global cause of death and disability.
  • Current treatments like reperfusion and neuroprotection have limitations including narrow time windows, poor drug bioavailability, and adverse effects.

Purpose of the Study:

  • To provide a comprehensive overview of nanomaterial-based drug delivery systems for ischemic stroke treatment.
  • To identify optimal combinations of nanocarriers, targeting ligands, and stimulus-responsive release factors.
  • To highlight future research directions and implications for novel ischemic stroke therapies.

Main Methods:

  • Review of current literature on nanomaterial-based drug delivery systems.
  • Analysis of nanocarrier types, targeting strategies, and drug release mechanisms.
  • Identification of key components for effective ischemic stroke treatment.

Main Results:

  • Nanomaterial systems offer extended half-life, increased bioavailability, targeted delivery, controlled release, and reduced toxicity.
  • These characteristics enhance the therapeutic efficacy of drugs used in ischemic stroke treatment.
  • Specific combinations of nanocarriers, ligands, and release stimuli can be tailored for improved outcomes.

Conclusions:

  • Nanomaterial-based drug delivery systems represent a promising approach to overcome limitations in current ischemic stroke treatments.
  • Further research into optimizing nanocarrier design, targeting specificity, and controlled release is crucial.
  • This review provides a foundation for developing next-generation, effective treatments for ischemic stroke.