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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

276
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
276
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Updated: Jul 7, 2025

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Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches.

Aditi Negi1, Shubham Nimbkar2, Jeyan Arthur Moses1

  • 1Computational Modeling and Nanoscale Processing Unit, National Institute of Food Technology, Entrepreneurship and Management-Thanjavur, Ministry of Food Processing Industries, Government of India, Thanjavur 613005, Tamil Nadu, India.

Pharmaceutics
|December 23, 2023
PubMed
Summary

Particle engineering optimizes dry powder inhalers for better lung delivery and therapeutic effects. Future technologies promise improved inhaled therapies, enhancing patient quality of life.

Keywords:
aerosolizationdry powder inhalerparticle engineeringpulmonary deliverytherapeutic efficiency

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biomedical Engineering

Background:

  • Effective delivery of inhaled therapeutics relies on respirable particles with precise physicochemical properties.
  • Particle characteristics significantly influence aerodynamic performance, lung deposition, and overall therapeutic efficacy of dry powder formulations.

Purpose of the Study:

  • To review physicochemical properties impacting dry powder inhaler performance.
  • To present advances in particle preparation techniques for optimizing therapeutic outcomes.
  • To highlight futuristic particle engineering approaches and their potential challenges.

Main Methods:

  • Review of physicochemical properties relevant to particle engineering.
  • Analysis of top-down and bottom-up particle preparation techniques.
  • Exploration of emerging technologies like electrospraying, inkjet printing, thin film freeze drying, and supercritical processes.

Main Results:

  • Physicochemical properties are critical determinants of aerodynamic performance and therapeutic efficacy.
  • Particle engineering strategies have evolved significantly over the past century, with recent innovations.
  • Novel techniques offer enhanced control over particle properties for improved drug delivery.

Conclusions:

  • Advanced particle engineering is key to optimizing inhaled therapeutic ingredient delivery.
  • Futuristic approaches hold significant promise for reshaping drug delivery and improving patient outcomes.
  • Continued innovation in particle engineering can enhance quality of life for patients with respiratory and other diseases.