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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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Colorectal Cancer Stem Cells and Targeted Agents.

Haobin Zhao1,2, Ruining Han3, Zhankun Wang4

  • 1Department of General Practice, People's Hospital of Longhua, 38 Jinglong Jianshe Road, Shenzhen 518109, China.

Pharmaceutics
|December 23, 2023
PubMed
Summary
This summary is machine-generated.

Targeting colorectal cancer stem cells (CR-CSCs) is crucial for overcoming treatment resistance and preventing metastasis. This review details CR-CSC characteristics, regulatory pathways, and emerging therapeutic strategies for improved colorectal cancer treatment.

Keywords:
Lgr5Wnt signaling pathwaycolorectal cancer stem cellssingle-cell omics technology

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Area of Science:

  • Oncology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Cancer stem cells (CSCs) drive tumor progression, metastasis, and therapy resistance.
  • Colorectal cancer (CRC) remains a significant global health challenge with high mortality.
  • Colorectal cancer stem cells (CR-CSCs) are key drivers of CRC progression and recurrence.

Purpose of the Study:

  • To provide a comprehensive overview of colorectal cancer stem cells (CR-CSCs).
  • To summarize the origin, biomarkers, cultivation, and research techniques for CR-CSCs.
  • To review signaling pathways and therapeutic strategies targeting CR-CSCs.

Main Methods:

  • Literature review of CR-CSC research.
  • Summary of CR-CSC identification and cultivation methods.
  • Analysis of signaling pathways (Wnt, JAK/STAT3, Notch, Hh) regulating CR-CSC stemness.
  • Review of current and emerging anti-CR-CSC drugs and therapies.

Main Results:

  • CR-CSCs possess self-renewal and differentiation capacities, contributing to metastasis and resistance.
  • Key signaling pathways like Wnt, JAK/STAT3, Notch, and Hh are critical for CR-CSC stemness.
  • Various biomarkers and research techniques aid in CR-CSC identification and study.
  • Emerging drugs target specific pathways and regulators to eliminate CR-CSCs.

Conclusions:

  • Targeting CR-CSCs offers a promising strategy to inhibit metastasis, enhance treatment efficacy, and reduce recurrence in colorectal cancer.
  • Understanding CR-CSC biology and regulatory pathways is essential for developing novel therapeutic agents.
  • This review provides insights into current anti-CR-CSC agents and potential future therapies.