Lateralized audiogenic seizure: motor asymmetries exhibited and the effects of interrupted stimulation

Sensitized SJL/J mice were monaurally tested for susceptibility to sound-induced seizure. The acoustic stimulation was interrupted for 15 s at various points during the biphasic pattern of running which these mice characteristically exhibit before seizing. Asymmetries of run directions and side of fall were noted. In addition, a dramatic reduction in seizure incidence was found when the interruption either extended into the period when the later burst of running would have occurred or began during this running burst. Finally, the results indicate that the latencies to the later running burst and the subsequent seizure are determined at or about the time of the onset of the first burst of running.