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Related Experiment Videos

Does digoxin sensitize left ventricular mechanoreceptors?

A Vogt, S Bretschneider, H Dal Ri

    Basic Research in Cardiology
    |November 1, 1986
    PubMed
    Summary

    Digoxin does not affect left ventricular mechanoreceptors, suggesting digitalis glycosides sensitize cardiopulmonary baroreflexes through central nervous system effects, not direct receptor interaction.

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    Area of Science:

    • Cardiovascular Physiology
    • Neuropharmacology
    • Cardiac Electrophysiology

    Background:

    • Left ventricular mechanoreceptors are activated by coronary artery occlusion, triggering depressor reflexes.
    • Digitalis glycosides are known to sensitize cardiopulmonary baroreflexes.
    • The precise mechanism of digitalis-induced baroreflex sensitization remains unclear.

    Purpose of the Study:

    • To investigate the effect of digoxin on the activity of left ventricular mechanoreceptors.
    • To determine if digoxin sensitizes these receptors, which could explain baroreflex changes.
    • To elucidate the role of peripheral versus central mechanisms in digitalis glycoside effects on cardiovascular reflexes.

    Main Methods:

    • Afferent nerve fibre activity from left ventricular mechanoreceptors was recorded in anesthetized cats.
    • Recordings were taken before and after intravenous administration of digoxin (15 µg/kg).
    • Mechanoreceptor activity was assessed under spontaneous conditions and during temporary coronary artery occlusion.

    Main Results:

    • Digoxin did not alter the spontaneous activity of left ventricular mechanoreceptor afferent nerve fibres.
    • Digoxin did not affect the maximum activity of these receptors during coronary artery occlusion.
    • Therapeutic doses of digoxin showed no sensitizing effect on these specific mechanoreceptors.

    Conclusions:

    • Digoxin does not sensitize left ventricular mechanoreceptors with vagal afferent fibres.
    • The observed sensitization of cardiopulmonary baroreflexes by digitalis glycosides is likely mediated by central nervous system effects.
    • This study suggests a central mechanism for digitalis glycoside action on cardiovascular reflex sensitivity.

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