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Published on: June 26, 2013
Functional Brain Networks of Minor and Well-Structured Major Hallucinations in Parkinson's Disease
Kyoungwon Baik1, Yae Ji Kim2,3, Mincheol Park4,5
1Department of Neurology, Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
Background:
Minor hallucinations (mHs) and well-structured major hallucinations (MHs) are common symptoms of Parkinson's disease (PD) psychosis.
Objectives:
To investigate the resting-state networks (RSNs) in patients with PD without hallucinations (PD-nH), with mH (PD-mH), and with MH (PD-MH).
Methods:
A total of 73 patients with PD were enrolled (27 PD-nH, 23 PD-mH, and 23 PD-MH). Using seed-based functional connectivity analyses, we investigated the RSNs supposedly related to hallucinations in PD: the default mode network (DMN), executive control network (ECN), dorsal attention network (DAN), ventral attention network (VAN), and visual network (VN). We compared the cognitive function and RSN connectivity among the three groups. In addition, we performed a seed-to-seed analysis to examine the inter-network connectivity within each group using the corresponding RSN seeds.
Results:
PD-MH group had lower test scores for attention and visuospatial functions compared with those in the other groups. The connectivity of the right intracalcarine cortex within the DAN was lower in the PD-MH group than in the others. The PD-mH and PD-MH groups showed higher connectivity in the left orbitofrontal cortex within DMN compared with the PD-nH group, whereas the connectivity was lower in the right middle frontal gyrus (MFG) within ECN, precuneus cortex within VAN, right middle temporal gyrus and precuneus cortex within DAN, and left MFG within VN. The PD-mH and PD-MH groups showed different inter-network connectivity between the five RSNs, especially regarding DAN connectivity.
Conclusions:
DAN dysfunction may be a key factor in the progression from mH to MH in patients with PD. © 2023 International Parkinson and Movement Disorder Society.
Insights
Dorsal attention network (DAN) dysfunction is key in Parkinson's disease psychosis progression. This study found altered resting-state network connectivity in patients with minor hallucinations (mH) and major hallucinations (MH).
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Parkinson's disease (PD) psychosis commonly features minor hallucinations (mH) and major hallucinations (MH).
- Understanding the neural underpinnings of these hallucinations is crucial for patient care.
Purpose of the Study:
- To investigate differences in resting-state networks (RSNs) among patients with PD without hallucinations (PD-nH), PD with mH (PD-mH), and PD with MH (PD-MH).
- To identify specific RSNs associated with the severity of hallucinations in Parkinson's disease.
Main Methods:
- Functional connectivity analyses of RSNs (DMN, ECN, DAN, VAN, VN) in 73 PD patients (27 PD-nH, 23 PD-mH, 23 PD-MH).
- Comparison of cognitive function and RSN connectivity across the three groups.
- Seed-to-seed analysis to examine inter-network connectivity within each group.
Main Results:
- The PD-MH group exhibited lower attention and visuospatial function scores.
- Reduced connectivity within the dorsal attention network (DAN) was observed in the PD-MH group.
- Altered connectivity in the default mode network (DMN), executive control network (ECN), ventral attention network (VAN), and visual network (VN) was noted in hallucinating PD patients.
Conclusions:
- Dorsal attention network (DAN) dysfunction appears critical in the progression from minor to major hallucinations in Parkinson's disease.
- Specific RSN alterations correlate with the presence and severity of hallucinations in PD patients.
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