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Safety of fluoroquinolones
J Barberán1, A de la Cuerda, M I Tejeda González
1José Barberán, Hospital Universitario HM Montepríncipe, Facultad HM Hospitales de Ciencias de la Salud, Universidad Camilo José Cela, Madrid, Spain. jose.barberan@ucjc.edu.
Fluoroquinolones (FQs), common antibiotics, carry risks of severe, long-lasting adverse effects like tendon rupture and aortic aneurysm. This review covers these threats and alternatives.
Area of Science:
- Pharmacology
- Toxicology
- Infectious Diseases
Background:
- Fluoroquinolones (FQs) are widely prescribed antibiotics.
- Initial trials suggested good tolerability.
- Post-marketing studies reveal serious adverse effects.
Purpose of the Study:
- To review significant adverse effects of fluoroquinolones.
- To discuss regulatory warnings regarding FQs.
- To explore alternative therapeutic options.
Main Methods:
- Literature review of epidemiological studies.
- Analysis of regulatory agency communications.
- Synthesis of information on FQ-associated toxicities.
Main Results:
- FQs linked to severe, persistent adverse effects.
- Neurotoxicity and collagen degradation are key concerns.
- Examples include tendonitis, rupture, aortic aneurysm, retinal detachment.
Conclusions:
- Fluoroquinolones pose significant risks beyond initial assessments.
- Regulatory agencies have issued warnings.
- Therapeutic alternatives should be considered for patient safety.
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