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Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Classification of Skeletal Muscle Relaxants01:28

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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
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Stretching is not essential for managing MS spasticity: A randomized controlled trial.

Cinda L Hugos1, Sandra K Joos2, Suzanne E Perumean-Chaney3

  • 1VA Portland Health Care System and Department of Neurology, Oregon Health & Science University, Portland, OR, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 23, 2023
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Summary

Daily stretching, recommended for multiple sclerosis (MS) spasticity, showed no significant difference compared to range of motion exercises. Both interventions improved MS spasticity, challenging the necessity of stretching alone.

Keywords:
Spasticityexerciserehabilitationstretchingsymptom management

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Clinical guidelines and expert opinion recommend daily stretching for multiple sclerosis (MS) spasticity.
  • However, high-powered clinical trials have not yet validated this recommendation.

Purpose of the Study:

  • To compare the effectiveness of a guideline-based spasticity education and stretching program (MS Spasticity: Take Control - STC) against a control program (spasticity education and range of motion - ROM exercises).
  • To evaluate the impact of these interventions on the severity of MS spasticity.

Main Methods:

  • 231 ambulatory individuals with self-reported MS spasticity were randomized into STC or ROM groups.
  • Interventions were delivered in group classes, initially face-to-face and later virtually due to COVID-19.
  • The primary outcome, Multiple Sclerosis Spasticity Scale (MSSS) scores, was assessed at 1 and 6 months post-intervention.

Main Results:

  • No statistically significant difference in MSSS scores was observed between the STC and ROM groups at the 1-month primary endpoint.
  • Both groups demonstrated significant mean improvements in MSSS scores and most secondary outcomes at both 1 and 6 months.

Conclusions:

  • Education incorporating stretching exercises and education incorporating range of motion exercises may yield similar improvements in MS spasticity.
  • The findings suggest that stretching may not be uniquely essential for managing MS spasticity, as other exercise modalities show comparable benefits.