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Updated: Jul 7, 2025

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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
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[An exemplificative case of constrictive pericarditis].
Ciro Pollio Benvenuto1, Gabriella Locorotondo1, Antonio Maria Leone1
1Dipartimento di Scienze Cardiovascolari, Università Cattolica del Sacro Cuore, Roma.
Summary
Constrictive pericarditis, a rare heart condition, causes heart failure. Early diagnosis is crucial, as this case highlights, even when symptoms mimic liver cirrhosis, necessitating pericardiectomy and potentially liver transplant.
Area of Science:
- Cardiology
- Gastroenterology
Background:
- Constrictive pericarditis is a rare but fatal condition causing heart failure through pericardial fibrosis and diastolic dysfunction.
- Its insidious presentation with venous congestion, hepatomegaly, and ascites often delays diagnosis.
Observation:
- A young adult with a prior hepatic cirrhosis diagnosis presented with symptoms mimicking advanced liver disease.
- Investigations revealed constrictive pericarditis as the underlying cause.
Findings:
- The patient underwent successful pericardiectomy, alleviating venous congestion.
- Despite surgical success, the patient still required a liver transplant, indicating irreversible liver damage.
Implications:
- This case underscores the importance of considering constrictive pericarditis in patients with unexplained ascites and venous congestion, even with co-existing liver disease.
- Timely diagnosis and treatment of constrictive pericarditis are vital to prevent irreversible organ damage and improve patient outcomes.
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