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ALSUntangled #73: Lion's Mane.

Maya Muhanna1, Issac Lund1, Mark Bromberg2

  • 1Medical College of Georgia at Augusta University, Augusta, GA, USA.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|December 23, 2023
PubMed
Summary
This summary is machine-generated.

Lion's Mane mushroom shows potential neuroprotective effects but lacks sufficient evidence for treating Amyotrophic Lateral Sclerosis (ALS). Further research in ALS models and clinical trials is needed to determine efficacy and safety.

Keywords:
ALSHericium erinaceusLion’s Mane

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Traditional Medicine

Background:

  • Lion's Mane (Hericium erinaceus) is a mushroom used in traditional Asian and European medicine.
  • It exhibits anti-inflammatory, neuroprotective, and neurite growth-promoting properties in preclinical studies.
  • A small trial suggested temporary cognitive improvement in mild cognitive impairment, but this requires replication.

Purpose of the Study:

  • To review the current evidence for Lion's Mane in neurodegenerative diseases, specifically Amyotrophic Lateral Sclerosis (ALS).
  • To assess the potential mechanisms of action and safety profile of Lion's Mane.
  • To determine if current data supports its use in ALS treatment.

Main Methods:

  • Literature review of studies on Lion's Mane, including cell models, animal models, and human trials.
  • Analysis of reported mechanisms of action related to neuroprotection.
  • Evaluation of safety data and adverse event reports.

Main Results:

  • Preclinical data suggests neuroprotective mechanisms relevant to neurodegenerative diseases.
  • One small human trial indicated temporary cognitive benefits in mild cognitive impairment.
  • No studies have investigated Lion's Mane in ALS cell or animal models or in human ALS patients.
  • Lion's Mane is generally safe in powder/capsule form, but fresh mushroom use led to one anaphylaxis case.

Conclusions:

  • Current evidence is insufficient to support Lion's Mane for ALS treatment.
  • While preclinical data is promising, rigorous studies in ALS models and human trials are essential.
  • Further research is recommended to establish efficacy and safety in ALS patients.