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Updated: Jul 7, 2025

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
Published on: October 24, 2018
The epigenome under pressure: On regulatory adaptation to chronic stress in the brain
Rodrigo G Arzate-Mejia1, Nancy V N Carullo2, Isabelle M Mansuy3
1Laboratory of Neuroepigenetics, Brain Research Institute, Medical Faculty of the University of Zurich and Institute of Neurosciences, Department of Health Science and Technology of the Swiss Federal Institute of Technology, Neuroscience Center Zurich, Switzerland. Electronic address: https://twitter.com/RodrigoArzt.
Abstract:
Chronic stress (CS) can have long-lasting consequences on behavior and cognition, that are associated with stable changes in gene expression in the brain. Recent work has examined the role of the epigenome in the effects of CS on the brain. This review summarizes experimental evidence in rodents showing that CS can alter the epigenome and the expression of epigenetic modifiers in brain cells, and critically assesses their functional effect on genome function. It discusses the influence of the developmental time of stress exposure on the type of epigenetic changes, and proposes new lines of research that can help clarify these changes and their causal involvement in the impact of CS.
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