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Updated: Jul 7, 2025

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans
Zhi-Fei Hu1, Kan Zhong1, Hongzhi Cao1
1Key Laboratory of Marine Drugs of Ministry of Education, Shandong Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 266003, China; Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao, Shandong, 266237, China.
Abstract:
Glycosylation is one of the most common post-translational modifications of proteins, which plays essential roles in regulating the biological functions of proteins. Efficient and versatile methods for the synthesis of homogeneous and well-defined N- and O-glycans remain an urgent need for biological studies and biomedical applications. Despite their structural complexity, tremendous progress has been made in the synthesis of N- and O-glycans in recent years. This review discusses some recent advances in the enzymatic and chemoenzymatic synthesis of N- and O-glycans.
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