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Published on: December 26, 2015
Effects of the combination of neurostimulation techniques in patients with mental disorders: A systematic review
Virginie Moulier1, Clémence Isaac2, Olivier Guillin3
1University Department of Psychiatry, Centre d'Excellence Thérapeutique - Institut de Psychiatrie - Centre Hospitalier du Rouvray, Sotteville-lès-Rouen, France; EPS Ville Evrard, Pôle 93G03, Centre de Recherche Clinique, Neuilly-sur-Marne, France.
Background:
despite years of development, response to neurostimulation remains partial and variable. Combining techniques could improve clinical efficacy and tolerance.
Objective:
to examine the literature on the effects of combining several neurostimulation techniques in patients with mental disorders.
Methods:
this systematic review follows the PRISMA guidelines RESULTS: 23 studies were included. The most studied combination was electroconvulsive therapy (ECT) along with another neurostimulation technique in depression. The RCTs that showed a significant effect targeted the left dorsolateral prefrontal cortex with high-frequency repetitive transcranial magnetic stimulation, before ECT. Combining neurostimulation techniques is a promising field of research.

