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Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
Published on: September 22, 2023
1.7K
Does gut brain axis has an impact on Parkinson's disease (PD)?
Ajay Elangovan1, Bhawna Dahiya1, Laxmi Kirola2
1Human Cytogenetics and Stem Cell Laboratory, Department of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda 151401, Punjab, India.
Ageing Research Reviews
|December 23, 2023
Summary
Gut microbiota (GM) and enteroendocrine cells (EECs) significantly influence Parkinson's Disease (PD) pathophysiology. This review explores their roles, metabolites, and potential therapeutic targets for PD.
Area of Science:
- Neuroscience
- Gastroenterology
- Microbiology
Background:
- Parkinson's Disease (PD) is a prevalent neurological disorder with an unknown cause.
- Gut microbiota (GM) plays a critical role in brain maintenance and neurological conditions.
- Enteroendocrine cells (EECs) regulate the gut-brain axis, influencing neurological diseases.
Purpose of the Study:
- To elucidate the role of GM and EECs in PD pathophysiology.
- To identify metabolites and compounds interacting with PD genes.
- To review current understanding and therapies related to EECs and PD.
Main Methods:
- Literature review focusing on GM, EECs, and PD.
- Bioinformatical analysis of metabolites and compounds affecting PD genes.
- Discussion of mechanisms, identification, and current therapies.
Main Results:
- GM and its metabolites are implicated in PD pathogenesis.
- EECs mediate gut-brain communication relevant to PD.
- Specific metabolites and compounds may interact with PD-related genes.
Conclusions:
- GM and EECs are crucial players in PD.
- Understanding these interactions may reveal new therapeutic strategies for PD.
- Further research into gut-brain axis modulation holds promise for PD treatment.
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