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Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements
Rupesh Raina1, Swathi Jothi2, Dieter Haffner3
1Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA; Department of Nephrology, Akron Children's Hospital, Akron, Ohio, USA.
Kidney International
|December 23, 2023
Summary
Focal segmental glomerular sclerosis (FSGS) recurrence post-transplant leads to graft loss. This review proposes consensus guidelines for managing recurrent FSGS, addressing risk factors and treatment, though more research is needed.
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- Focal segmental glomerular sclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage kidney disease.
- Recurrent FSGS post-kidney transplantation results in significant allograft loss and increased patient mortality.
- Current lack of consensus guidelines hinders risk identification and management of recurrent FSGS.
Conclusions:
- Consensus guidelines for recurrent FSGS have been established, offering a framework for clinical practice.
- The guidelines highlight the need for further research to enhance the management and prediction of recurrent FSGS.
- Addressing recurrent FSGS is crucial for improving kidney allograft survival rates.
