Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adenosine release into venous plasma during free flow exercise.

B D Fuchs, M W Gorman, H V Sparks

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |March 1, 1986
    PubMed
    Summary

    Exercise increases adenosine release from muscles into the blood. This study measured adenosine release during exercise, finding a significant increase, supporting its role in muscle activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of airway pressure display on interobserver agreement in the assessment of vascular pressures in patients with acute lung injury and acute respiratory distress syndrome.

    Critical care medicine·2005
    Same author

    Cellular and molecular actions of adrenomedullin in glomerular mesangial cells.

    Peptides·2002
    Same author

    Underappreciation of sleep disorders as a cause of motor vehicle crashes.

    The American journal of emergency medicine·2001
    Same author

    FK506 promotes adenosine release from endothelial cells via inhibition of adenosine kinase.

    European journal of pharmacology·2001
    Same author

    K(ATP)(+) channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation.

    American journal of physiology. Heart and circulatory physiology·2001
    Same author

    Feedforward sympathetic coronary vasodilation in exercising dogs.

    Journal of applied physiology (Bethesda, Md. : 1985)·2000

    Area of Science:

    • Physiology
    • Biochemistry

    Background:

    • Adenosine plays a role in regulating blood flow and cellular metabolism.
    • Understanding adenosine's role during exercise is crucial for comprehending exercise physiology.

    Purpose of the Study:

    • To measure adenosine release into venous plasma as an indicator of interstitial adenosine concentration.
    • To investigate the relationship between exercise-induced hyperemia and adenosine release.

    Main Methods:

    • Isolated, blood-perfused dog calf muscles were subjected to 6 Hz exercise for 10 minutes.
    • Plasma adenosine concentration was measured using High-Performance Liquid Chromatography (HPLC).
    • Adenosine release was calculated using plasma flow and arteriovenous adenosine concentration differences.

    Related Experiment Videos

    Main Results:

    • Adenosine release increased significantly from -0.1 +/- 0.1 nmole/min/100 g at rest to 6.6 +/- 4.6 nmole/min/100 g during 6-Hz exercise.
    • Isoproterenol infusion, which increased blood flow, did not elevate adenosine release.
    • Inhibition of 5'-nucleotidase with AOPCP did not prevent the exercise-induced increase in adenosine release.

    Conclusions:

    • Interstitial adenosine concentration increases during sustained twitch exercise.
    • This increase in interstitial adenosine leads to greater release into the venous plasma.
    • Adenosine release is a key component of the physiological response to exercise hyperemia.