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Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

Vaccinations

Vaccinations

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Related Experiment Video

Updated: Jul 7, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

COVID-19 Vaccines and Axillary Nerve Dysfunction: A Case Report.

Andrea McCarthy¹, Barry O'Neill²

¹Trauma and Orthopedic Surgery, St. James's Hospital, Dublin, IRL.

|December 25, 2023

Summary

This summary is machine-generated.

COVID-19 vaccines can cause neuritis and neuropathy, affecting nerves like the axillary nerve. This report details a case of axillary nerve symptoms post-vaccination and the patient

Keywords:

axillary nerve injury covid 19 covid-19 vaccine complication deltoid muscle trauma and orthopedics

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Area of Science:

Neurology
Immunology
Vaccinology

Background:

The global COVID-19 pandemic necessitated rapid vaccine development and deployment.
Neuritis and neuropathy are known potential side effects of intramuscular injections, including influenza vaccines.

Observation:

A case study involving a 43-year-old female patient is presented.
The patient developed symptoms related to the axillary nerve following COVID-19 vaccination.

Findings:

The patient experienced axillary nerve symptoms, consistent with vaccine-induced neuritis/neuropathy.
The case documents the patient's recovery from these neurological symptoms.

Implications:

This case highlights a potential neurological side effect of COVID-19 vaccines.
Further research into vaccine-associated neurological complications is warranted.
Understanding these adverse events is crucial for vaccine safety monitoring.