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Longitudinal Associations Between Mild Behavioral Impairment, Sleep Disturbance, and Progression to Dementia

Dinithi Mudalige1, Dylan X Guan1, Maryam Ghahremani2

  • 1University of Calgary, Calgary, AB, Canada.

Journal of Alzheimer'S Disease Reports
|December 25, 2023
PubMed
Abstract

Insights

Mild behavioral impairment (MBI) and sleep disturbance (SD) have a bidirectional relationship. Older adults with both MBI and SD show increased dementia risk, suggesting combined assessment for improved screening.

Area of Science:

  • Neurology
  • Gerontology
  • Psychiatry

Background:

  • Clinical guidelines suggest incorporating non-cognitive markers like mild behavioral impairment (MBI) and sleep disturbance (SD) into dementia screening.
  • Early detection of dementia can be improved by considering these markers.

Purpose of the Study:

  • To investigate the longitudinal associations between MBI, SD, and the incidence of dementia.
  • To explore the bidirectional relationship between MBI and SD over time.

Main Methods:

  • Utilized data from the National Alzheimer's Coordinating Center (NACC) in the United States.
  • Employed Cox proportional hazard regressions with time-dependent variables to model associations.
  • Analyzed incident SD in MBI-positive individuals, incident MBI in SD-positive individuals, and incident dementia based on MBI and SD status.

Main Results:

  • Older adults with MBI at baseline had a 3.1-fold higher rate of developing SD.
  • Older adults with baseline SD had a 1.5-fold higher rate of developing MBI.
  • The rate of dementia development was 2.2-fold greater in individuals with both MBI and SD compared to those with SD alone.

Conclusions:

  • A bidirectional relationship exists between MBI and SD.
  • The co-occurrence of MBI and SD significantly increases dementia risk in older adults.
  • Assessing for both MBI and SD may enhance dementia screening protocols.
Keywords:
Alzheimer’s diseasedementialongitudinal studiesneurobehavioral manifestationssleep disorders

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