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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

294
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

345
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
345
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

562
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
562
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

545
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
545
Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

6.2K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
6.2K
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

538
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
538

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Related Experiment Video

Updated: Jul 7, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Roadmap on multifunctional materials for drug delivery.

Benjamin Nottelet1,2, Sytze Buwalda3, Cornelus F van Nostrum4

  • 1IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.

Jphys Materials
|December 25, 2023
PubMed
Summary

This roadmap highlights recent advances in materials for drug delivery systems (DDSs), focusing on how multifunctional materials address current challenges and drive future innovation in biomaterial science.

Keywords:
drug deliveryhydrogelsmultifunctional materialsnanomaterialspolymersmart

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Area of Science:

  • Biomaterial Science
  • Materials Science
  • Nanotechnology

Background:

  • Drug delivery systems (DDSs) are crucial for effective therapeutics.
  • Advancements in materials science are key to improving DDS performance.
  • Multifunctional materials offer enhanced capabilities for modern DDSs.

Purpose of the Study:

  • To provide a snapshot of recent advances in materials for DDSs.
  • To emphasize the role of multifunctional materials in overcoming DDS challenges.
  • To outline future perspectives and required advances in biomaterial science for DDSs.

Main Methods:

  • This roadmap synthesizes current research and expert perspectives.
  • It reviews the status of the field and identifies key challenges.
  • Focuses on the latest developments in multifunctional materials for DDSs.

Main Results:

  • Multifunctional materials are pivotal for enhancing modern DDS performance.
  • Significant challenges remain in biomaterial science for DDS development.
  • The roadmap identifies critical areas for future research and collaboration.

Conclusions:

  • Multifunctional materials are essential for next-generation drug delivery systems.
  • Continued innovation in biomaterial science is needed to meet evolving healthcare demands.
  • Collaboration across disciplines will accelerate progress in advanced DDSs.