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[A case of pleomorphic xanthoastrocytoma]
No to Shinkei = Brain and Nerve
|December 1, 1986
Summary
This report details a rare pleomorphic xanthoastrocytoma case in a 12-year-old boy. Successful surgical removal led to a positive 3-year outcome with no tumor recurrence or neurological deficits.
Area of Science:
- Neuro-oncology
- Neuropathology
Background:
- Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor.
- PXA typically affects children and young adults.
Observation:
- A 12-year-old boy presented with a history of seizures.
- CT imaging revealed a right frontal lobe lesion with calcification and contrast enhancement.
- Surgical exploration identified a cystic tumor with a solid nodular component.
Findings:
- Histological examination showed marked pleomorphism, vacuolated cytoplasm, giant cells, and multinucleated cells without necrosis or mitosis.
- Immunohistochemistry confirmed glial fibrillary acidic protein (GFAP) expression.
- Electron microscopy revealed glial filaments and lipid granules.
Implications:
- Complete resection of the nodular tumor and subtotal removal of the cyst wall resulted in a favorable prognosis.
- This case highlights the importance of accurate diagnosis and surgical management of PXA.
- Long-term follow-up is crucial for monitoring potential recurrence.