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Controlled electroactive release from solid-state conductive elastomer electrodes.

Christopher A R Chapman1,2, Shanila Fernandez-Patel3, Nusrat Jahan2

  • 1School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK.

Materials Today. Bio
|December 25, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a conductive elastomer platform for targeted drug delivery. This electrophoretic system precisely releases charged molecules, like methylene blue and fluorescein, directly to tissues, enabling potential multi-drug therapies.

Keywords:
Conducting polymerConductive elastomerControlled releaseElectrophoretic releaseTargeted drug delivery

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery Systems

Background:

  • Electrophoretic platforms offer precise control over charged molecule delivery.
  • Conductive elastomers provide flexible and biocompatible electrode materials.
  • Targeted delivery to tissues requires advanced methods for controlled release.

Purpose of the Study:

  • To develop a conductive elastomer (CE) based electrophoretic platform for direct tissue delivery.
  • To demonstrate controlled electrophoretic release of charged molecules using the CE platform.
  • To investigate the potential for selective and sequential release of multiple drugs.

Main Methods:

  • Fabrication of an elastomer-based electrode incorporating poly(3,4-ethylenedioxythiophene) nanowires.
  • Application of controlled voltage for electrophoretic delivery of methylene blue (MB) and fluorescein (FLSC).
  • Quantification of released MB and FLSC and assessment of selective/sequential release.

Main Results:

  • Achieved controlled electrophoretic delivery of MB and FLSC with applied voltage.
  • Demonstrated significant electroactive release: 33.19 ± 6.47 μg of MB and 22.36 ± 3.05 μg of FLSC.
  • Showcased selective and sequential release of oppositely charged molecules from a single CE device.

Conclusions:

  • The developed conductive elastomer electrophoretic platform enables efficient, targeted delivery of charged molecules to tissues.
  • The platform allows for controlled and significant electroactive release of model drugs.
  • The ability for selective and sequential release highlights its potential for multi-drug therapeutic applications.