Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation.

Area of Science:

• Coordination Chemistry
• Organic Synthesis
• Antimicrobial Research

Background:

• Vic-dioximes are versatile compounds with significant industrial and scientific applications.
• They serve as crucial ligands in the synthesis of numerous coordination compounds.
• Dichloroglyoxime derivatives are of particular interest due to their structural versatility.

Purpose of the Study:

• To synthesize and fully characterize novel vic-dioximes derived from dichloroglyoxime, p-aminobenzoic acid, and p-aminotoluene.
• To investigate the structural features of these synthesized compounds.
• To evaluate the antimicrobial potential of the synthesized vic-dioximes.

Main Methods:

• Synthesis of two distinct vic-dioximes.
• Structural elucidation using Infrared (IR) spectroscopy.
• Nuclear Magnetic Resonance (NMR) spectral analysis (1H, 13C, 15N).
• Single crystal X-ray diffraction for definitive structural confirmation.
• Antimicrobial activity testing against a panel of bacteria and fungi.

Main Results:

• Successful synthesis and characterization of two new vic-dioximes.
• Confirmation of structures through comprehensive spectroscopic and crystallographic analyses.
• One synthesized vic-dioxime, bis(di-p-aminotoluene)glyoxime mono-p-aminotoluene trihydrate, exhibited significant antimicrobial activity.
• The compound showed moderate to good efficacy against nonpathogenic and phytopathogenic bacteria, as well as fungi, with Minimum Inhibitory Concentrations (MIC) ranging from 70-150 μg/mL.

Conclusions:

• The study successfully synthesized and characterized novel vic-dioxime compounds.
• The structural data provides valuable insights into the coordination chemistry of these ligands.
• The identified antimicrobial activity suggests potential therapeutic or agricultural applications for these vic-dioximes.