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Related Experiment Videos

Nefopam excretion in human milk.

D T Liu, J M Savage, D Donnell

    British Journal of Clinical Pharmacology
    |January 1, 1987
    PubMed
    Summary

    Nefopam hydrochloride, taken for pain relief, was found in human milk at concentrations similar to maternal plasma. Infant exposure was minimal, representing less than 3% of the maternal dose.

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    Area of Science:

    • Pharmacology
    • Neonatal Medicine
    • Lactation Studies

    Background:

    • Post-episiotomy pain management often requires analgesics.
    • Assessing medication transfer into human milk is crucial for infant safety.
    • Nefopam hydrochloride is a non-opioid analgesic used for moderate to severe pain.

    Purpose of the Study:

    • To quantify nefopam hydrochloride concentrations in human milk and maternal plasma.
    • To determine the potential infant exposure to nefopam via breastfeeding.
    • To evaluate the safety of nefopam hydrochloride use in nursing mothers.

    Main Methods:

    • Human milk and plasma samples were collected from five healthy lactating mothers.
    • Nefopam hydrochloride dosage was 60 mg every four hours.
    • Concentrations were measured using a paired-ion reverse-phase high-performance liquid chromatography (h.p.l.c.) method.

    Main Results:

    • Nefopam was detected in human milk at concentrations comparable to maternal plasma (milk:plasma ratio 1.2 ± 0.7).
    • Estimated daily infant exposure was less than 0.05 mg/kg.
    • This exposure represents <3% of the maternal body weight-adjusted dose.

    Conclusions:

    • Nefopam hydrochloride transfers into human milk but at low levels.
    • Breastfeeding infants are likely to have minimal exposure to nefopam.
    • Nefopam hydrochloride may be considered for pain management in nursing mothers with caution.

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