Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.5K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

411
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
411
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

305
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
305

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe asthma and remission prospects in Europe (SHARP): insights from a multicentre observational study based on the European Severe Asthma Registry.

The Lancet. Respiratory medicine·2026
Same author

Clinical Features of Cellular Senescence Pathways in Severe Asthma.

Allergy·2026
Same author

Single-cell transcriptomics of granulocytes in asthma and atopic diseases.

Frontiers in molecular biosciences·2026
Same author

Asthma exacerbation profile of benralizumab for severe eosinophilic asthma (the BenRex study): a multicentre, prospective cohort study.

The Lancet. Respiratory medicine·2026
Same author

Clinical phenotypes of difficult-to-treat and mild asthma defined by cluster analysis.

Respiratory research·2026
Same author

Natural History of Alternaria Sensitisation and Association With Asthma and Rhinitis From Childhood to Adulthood.

Allergy·2026

Related Experiment Video

Updated: Jul 7, 2025

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.6K

How Does Mild Asthma Differ Phenotypically from Difficult-to-Treat Asthma?

Jennifer Naftel1, Heena Mistry1,2,3,4,5, Frances Ann Mitchell4

  • 1National Institute for Health Research (NIHR) Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Journal of Asthma and Allergy
|December 25, 2023
PubMed
Summary
This summary is machine-generated.

Mild asthma is often early-onset, characterized by type-2 inflammation and common comorbidities like anxiety and depression. Early assessment can prevent progression to severe disease.

Keywords:
difficult asthmamild asthmamultimorbiditytype 2 inflammation

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.3K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K

Related Experiment Videos

Last Updated: Jul 7, 2025

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.6K
Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.3K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K

Area of Science:

  • Pulmonology
  • Immunology
  • Epidemiology

Background:

  • The mild asthma phenotype is understudied despite representing the majority of asthma cases.
  • This study aims to characterize mild asthma and compare it to difficult-to-treat asthma.

Purpose of the Study:

  • To extensively characterize the mild asthma phenotype.
  • To compare the characteristics of mild asthma with difficult-to-treat asthma.

Main Methods:

  • Two real-world adult cohorts were assessed using identical methodologies: the Wessex AsThma CoHort of difficult asthma (WATCH) and a mild asthma cohort from the Epigenetics Of Severe Asthma (EOSA) study.
  • Data included clinical questionnaires, anthropometry, allergy and lung function testing, and biological samples (blood and sputum).

Main Results:

  • Mild asthma is predominantly early-onset, associated with type-2 (T2) inflammation (atopy, raised fractional exhaled nitric oxide (FeNO), eosinophilia) and preserved lung function.
  • High prevalence of comorbidities (depression, anxiety) and current smokers (20.9%) were observed in mild asthma.
  • Mild asthma shared T2-high inflammation and atopy with difficult asthma but had lower neutrophil counts and preserved lung function.

Conclusions:

  • Mild asthma is characterized by early onset, T2-high inflammation, current smoking, and significant multimorbidity.
  • Comprehensive early assessment of mild asthma patients may prevent progression to severe disease.