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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Emerging Futuristic Targeted Therapeutics: A Comprising Study Towards a New Era for the Management of TNBC

Tanuma Mistry1,2, Arijit Nath3, Ranita Pal1

  • 1Departments of Pathology and Cancer Screening.

American Journal of Clinical Oncology
|December 25, 2023
PubMed

Insights

Triple-negative breast cancer (TNBC) has poor outcomes due to resistance and heterogeneity. This review explores novel molecular and immune targets to improve TNBC treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Triple-negative breast cancer (TNBC) presents significant challenges due to its high lethality, chemoresistance, and extensive molecular heterogeneity.
  • Current treatment limitations include poor response rates, low survival, and frequent relapses, necessitating novel therapeutic avenues.
  • Existing targeted therapies combined with chemotherapy have yielded suboptimal outcomes for TNBC patients.

Approach:

  • This review comprehensively analyzes established treatment modalities for TNBC.
  • It further explores emerging molecular and immune-targeted therapeutics, detailing their mechanisms of action.
  • The review aims to identify potent novel treatments and strategies to overcome current therapeutic obstacles.

Key Points:

  • TNBC is characterized by chemoresistance and heterogeneity, contributing to poor prognosis.
  • Conventional treatments and current targeted therapies show limited efficacy.
  • Novel molecular and immune targets are crucial for developing more effective TNBC therapies.

Conclusions:

  • There is an urgent need for innovative treatments for triple-negative breast cancer.
  • Exploring molecular and immune targets offers promising strategies to improve patient outcomes.
  • This review provides insights into advanced therapeutic approaches for managing TNBC.

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