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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy
NaNa Fu1, Shuang Yuan2, Guang Yang3
1Department of Nephrology, ShouGuang Chinese Medicine Hospital, No.3353 ShengCheng Street, ShouGuang, 262700, People's Republic of China.
This study reports a unique case of protocadherin 7 (PCDH7) deposits in membranous nephropathy (MN) associated with M-type phospholipase A2 receptor (PLA2R). This finding enhances understanding of novel antigens in glomerular diseases.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Membranous nephropathy (MN) understanding has advanced with novel antigen discoveries.
- M-type phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) are key antigens in primary MN.
- Other antigens like EXT1/EXT2, NELL-1, SEMA3B, and PCDH7 are identified in remaining MN cases.
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