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Cyclic variation in onset of central retinal vein occlusion
Insights
Central retinal vein occlusion (CRVO) symptom onset occurs more frequently during colder months, from September to February. This seasonal pattern suggests potential links to changes in blood clotting and retinal blood flow.
Area of Science:
- Ophthalmology
- Retinal Vascular Diseases
- Circadian Rhythms
Background:
- Central retinal vein occlusion (CRVO) is a significant cause of vision loss.
- Understanding CRVO's epidemiological patterns can inform preventative strategies.
Purpose of the Study:
- To investigate the seasonal incidence of CRVO symptom onset.
- To identify potential correlations between CRVO onset and seasonal factors.
Main Methods:
- Retrospective analysis of 105 CRVO patients over a 5-year period.
- Statistical evaluation of symptom onset dates to identify seasonal variations.
Main Results:
- A statistically significant seasonal variation in CRVO onset was observed (p < 0.01).
- CRVO symptom onset was most frequent between September and February.
Conclusions:
- CRVO onset exhibits a distinct seasonal pattern, peaking in late autumn and winter.
- Seasonal changes in hemostasis and retinal perfusion may contribute to CRVO incidence.
Abstract:
We studied the seasonal incidence of onset of symptoms of central retinal vein occlusion (CRVO) in 105 patients over a 5-year period. Their onset showed a significant cyclic variation (p less than 0.01), being most frequent in the months September through to February. We believe this seasonal variation may in part reflect seasonal changes in haemostasis and retinal perfusion, though other unidentified factors play a significant role.