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Solid core liposomes with encapsulated colloidal gold particles.

K Gao, L Huang

    Biochimica Et Biophysica Acta
    |March 12, 1987
    PubMed
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    This study details the creation of solid core liposomes containing colloidal gold particles. The lipid composition, specifically the inclusion of triolein, influences the liposome

    Area of Science:

    • Biochemistry
    • Materials Science
    • Nanotechnology

    Background:

    • Liposomes are versatile drug delivery vehicles.
    • Encapsulating nanoparticles within liposomes presents unique challenges.
    • Controlling liposome structure is crucial for targeted delivery.

    Purpose of the Study:

    • To develop a method for preparing solid core liposomes encapsulating colloidal gold particles.
    • To investigate the effect of lipid composition on liposome structure.
    • To characterize the resulting solid core liposomes containing gold nanoparticles.

    Main Methods:

    • Preparation of agarose-gelatin microspherules as solid cores.
    • Incorporation of colloidal gold particles and protein coating.
    • Modified organic solvent spherule evaporation for liposome formation.

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  • Lipid mixture composition varied, notably with and without triolein.

    • Main Results:

    • Solid core liposomes with encapsulated colloidal gold particles were successfully prepared.
    • Liposomes formed with dioleoylphosphatidylcholine/cholesterol/dioleoylphosphatidylglycerol/triolein (4.5:4.5:1:1 molar ratio) exhibited a single bilayer membrane.
    • Absence of triolein resulted in multilamellar liposomes.
    • Both formulations contained hundreds to thousands of colloidal gold particles per liposome.

    Conclusions:

    • A novel method for creating solid core liposomes with encapsulated gold nanoparticles was established.
    • Triolein is essential for forming single bilayer solid core liposomes.
    • The developed liposomes hold potential for applications requiring nanoparticle encapsulation.